Watch Closely (two)pentobarbital will reduce the extent or impact of suvorexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Powerful CYP3A4 inducers may perhaps minimize suvorexant efficacy; if improved suvorexant dose needed, don't exceed twenty mg/daypentobarbital will reduce the extent or effect of bortezomib b